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Fluorescein
angiography, a clinical test to look at blood circulation inside
the back of the eye, aids in the diagnosis of retinal conditions
associated with diabetes, age-related macular degeneration, and
other eye abnormalities. The test can also help follow the course
of a disease and monitor its treatment. It may be repeated on multiple
occasions with no harm to the eye or body.
Fluorescein,
a harmless orange-red dye, is injected into a vein in the arm. The
dye travels through the body to the blood vessels in the retina,
the light-sensitive nerve layer at the back of the eye. A special
camera with a green filter flashes a blue light into the eye and
takes multiple photographs of the retina. The technique uses regular
photographic film. No X-rays are involved.
If
there are abnormal blood vessels, the dye leaks into the retina
or stains the blood vessels. Damage to the lining of the retina
or atypical new blood vessels may be revealed as well. These abnormalities
are determined through a careful interpretation of the photographs
by an ophthalmologist.
The
dye can discolor skin and urine until it is removed from the body
by the kidneys. There is little risk in having fluorescein angiography,
though some people may have mild allergic reactions to the dye.
Severe allergic reactions have been reported but very rarely. Being
allergic to X-ray dyes with iodine does not mean you'll be allergic
to fluorescein. Occasionally, some of the dye leaks out of the vein
at the injection site, causing a slight burning sensation that usually
goes away quickly.
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